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. 2010 Apr 27;18(7):1318–1329. doi: 10.1038/mt.2010.73

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Copyright © 2010 The American Society of Gene & Cell Therapy

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Humoral responses to capsid proteins after ATVRX or intramuscular (i.m.) vector delivery. Anti-AAV-2 capsid (a) IgG1 and (b) IgG2 subclass antibody titer measured by enzyme-linked immunosorbent assay; values are represented as average (n = 2 per time point) ± SD; animals received AAV-2 under immunosuppression (IS) by ATVRX at a dose of 1 × 10¹² vg/kg (group A), 3 × 10¹² vg/kg (group B), 8 × 10¹² vg/kg (group C) or without IS at a dose of 3 × 10¹² vg/kg either by ATVRX (group D) or i.m. (group E); x axis, time in days. ATVRX, afferent transvenular retrograde extravasation.