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. 2010 Apr 27;18(7):1318–1329. doi: 10.1038/mt.2010.73

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Copyright © 2010 The American Society of Gene & Cell Therapy

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Histology of muscle biopsies in dogs receiving AAV vectors by ATVRX or i.m. Hematoxylin and eosin staining of muscle biopsies obtained from the ATVRX dogs 6 months after gene transfer: (a) I07 and (b) H48, AAV-2, 3 × 10¹² vg/kg with IS; (c) M25, AAV-2, 8.5 × 10¹² vg/kg with IS; or (d) M13, AAV-6, 3 × 10¹² vg/kg with IS. (e) Hematoxylin and eosin staining on muscle from dog M14, AAV-2, 3 × 10¹² vg/kg, i.m. without IS. Asterisk denotes target limb. Black arrows indicate central nuclei, evidence of muscle regeneration. Images were all taken at a ×200 magnification. AAV, adeno-assocaited virus; ATVRX, afferent transvenular retrograde extravasation; G, gastrocnemius muscle; i.m., intramuscular; IS, immunosuppression; ST, semi-tendinosus muscle; VL, vastus lateralis muscle.