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. 2010 Apr 27;18(7):1373–1378. doi: 10.1038/mt.2010.74

Figure 3.

Figure 3

Correction of sulfatide storage in the CNS and balance beam test of B4MLD mice. (a) Sections of corpus callosum, hippocampal fimbria, and internal capsule were stained with alcian blue. Cells accumulating sulfatides were detected in nontreated and MIGMLD mice. By contrast, no significant sulfatide accumulation was detected in B4MLD mice. (Bar = 200 µm) (b,c) balance and motor coordination on the balance beam. Nontreated (n = 15), MIGMLD (n = 9), and B4MLD (n = 13) mice were trained to walk across round beams having a cross-sectional diameter of 20 mm or less to reach an enclosed safety platform. (b) The time needed (latency) to cross and (c) the number of slips were recorded in each trial. All animals were given three trials on the beams. *P < 0.05, **P < 0.001 compared to nontreated. B4MLD, HoxB4-transduced BM cells transplanted MLD mice; CNS, central nervous system; MIGMLD, GFP-transduced BM cells transplanted MLD mice.