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. 2010 Apr 27;18(7):1373–1378. doi: 10.1038/mt.2010.74

Figure 5.

Figure 5

Overexpression of HoxB4 is important for increasing the numbers of cells in the brain. Eight months after transplantation, mice were sacrificed and analyzed. (a) Percentage of engraftment detected by flow cytometry. *P < 0.05 compared to MIGMLD, (b) percentage of GFP+ in the brain. GFP+ area in the brain was calculated using Lumina Vision Software (Mitani). **P < 0.003 compared to MIGMLD and NTMLD, and (c) percentage of alcian blue+ in the brain. Alcian blue+ area in the brain was calculated by Lumina Vision Software. ***P < 0.01 compared to MIGMLD and NTMLD. Overexpression of HoxB4 is important for increasing the numbers of donor cells in the brain and for reduced the amount of stored sulfatides. B4MLD, HoxB4-transduced BM cells transplanted MLD mice; GFP, green fluorescent protein; MIGMLD, GFP-transduced BM cells transplanted MLD mice; NTMLD, nontransduced BM-transplanted MLD.