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Effect of timing and dose of VIP on liver transduction efficiency by HDΔ28E4LacZ. Hepatic β-galactosidase activity was determined 48 hours postinjection of 1 × 1012 vp/kg HDΔ28E4LacZ into C57BL/6 mice treated with VIP at various doses and times by intraperitoneal injection. Means ± SD shown (n = 5). HDAd, helper-dependent adenoviral vectors; VIP, vasoactive intestinal peptide; vp, vector particles.
