Figure 4.

Serum levels of IL-6, IL-12, AST, and ALT from mice injected with either 1 × 10¹² or 5 × 10¹² vp/kg of HDΔ28E4LacZ pretreated 30 minutes prior with either saline or VIP (10 nmol/mouse) by intraperitoneal injection. IL-6 and IL-12 levels were measured 6 hours postvector. AST and ALT levels were measured 24 hours postvector. Means ± SD shown (n ≥ 5). Background levels were 11.2 ± 8.5 pg/ml for IL-6, 24.8 ± 2.8 pg/ml for IL-12, 43 ± 14.3 U/l for AST, and 29 ± 4.2 U/l for ALT. ALT, alanine aminotransferase; AST, aspartate aminotransferase; IL, interleukin; VIP, vasoactive intestinal peptide.