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. 2010 May 27;285(31):23699–23710. doi: 10.1074/jbc.M110.123497

FIGURE 9.

FIGURE 9.

Integrin β5 serines 759 and/or 762 are necessary for PAK4 induced cell migration. A, flow cytometry analysis of integrin αvβ5 cell surface expression in CS-1 cells with or without stable expression of integrin β5-WT, β5-SS759,762AA, or β5-SS759,762EE. M1 shows mean intensity of the cells expressing αvβ5. B, cell migration onto VN of stable mixed clones of β5-WT, β5-SS759,762AA, and β5-SS759,762AA transiently co-expressing EGFP (open bars) or EGFP-PAK4 (solid bars). Bars represent mean values ± S.E. for three experiments. Statistically discernable differences as determined by t test are indicated (*, p ≤ 0.05).