Figure 2.
Serum IgG antibodies to PA (A) and S. Typhi LPS (B) in mice immunized with S. Typhi Ty21a strains expressing B. anthracis PA. Mice were primed i.n. on days 0, 28 and 56 with S. Typhi Ty21a strain carrying PA-encoding plasmids pSECPA and pVDL9.3PA83ec or empty plasmids pSEC10 and pVDL9.3. Curves are plotted upon the GMT for each group and bars indicate the 95% confidence intervals. Arrows indicate each immunization. * indicate differences between PA-expressing strains vs. strains carrying empty plasmids (p<0.001) at peak time points after each dose.