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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Neurogastroenterol Motil. 2010 May 13;22(8):909–e237. doi: 10.1111/j.1365-2982.2010.01508.x

Figure 2.

Figure 2

Analysis of distance from myenteric ganglia to detection sites in neonatal and adult guinea pigs. [A] and [B]: Photomicrographs of NOS-ir neurons in neonatal and adult tissues. A greater density of neurons and fibers within the same tissue area was observed in neonates [B] compared to adults [A]. The black circle indicates location of ganglia measurements using the BBD electrode, whilst the white circle indicates the location the BBD sensor is placed to conduct in-between recordings of NO production. The dashed white line indicates the maximal distance of NO is observed following release based upon diffusivity and consumption from a mathematical model. Scale bar for both photomicrographs: 100 µm. [C] The distance from myenteric ganglia to detection sites is greater in adults (n = 26) in comparison to neonates (n = 48, P < 0.001). Data expressed as mean ± SEM.