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Grade 3/4 Toxicity by dose level
| Toxicity * | 45 mg QD G 3/4 (N=12) |
30 mg QD G 3/4 (N=13) |
|---|---|---|
| ALT/AST | 2/0 | 1/0 |
| Fatigue | 2/2 | 4/0 |
| Diarrhea | 2/0 | - |
| Hypertension | 1/0 | 2/0 |
| Proteinuria | 2/0 | 1/0 |
| Hand-foot syndrome | 1/0 | - |
Events those were possible, probable or definitely related to study therapy
