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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Nat Genet. 2010 Jul 4;42(8):715–721. doi: 10.1038/ng.619

Figure 2. NF1 alterations in karyotypically complex sarcomas.

Figure 2

A. Somatic mutations in the NF1 protein in myxofibrosarcoma and pleomorphic liposarcoma (black triangles) and the position of the RasGAP and Cral domains (dark and light green respectively) are juxtaposed to known mutations in malignant peripheral nerve sheath tumors (MPNSTs; open triangles). B. Transcript expression according to copy number and sequence status in myxofibrosarcoma and pleomorphic liposarcoma compared to normal adipose tissue samples (black/red and green respectively, log2 expression from Affymetrix array profiling data; p-value=1.94×10−5, ANOVA; mutated tumors are indicated). One of the two R304* mutant tumors lacked expression data.