Table 4.
Predicted miRNA target seed sequences in the 3′ UTRs of genes involved in wnt signaling
miR-200b/c/429 | miR-200a* | miR-200a/141 | miR-203 | miR-205 | |
---|---|---|---|---|---|
APC | 7mer-m8 # | 7mer-1A | |||
CTNNB1 | 7mer-1A # | ||||
CTNNBIP1 | 7mer-1A | ||||
DIXDC1 | 8mer* | 7mer-m8* # | 8mer (2) | ||
DKK1 | 7mer-m8 | ||||
DKK2 | 7mer-m8 |
7mer-1A 7mer-m8 |
|||
DKK3 | * | 7mer-m8 (2) | |||
DKK4 | 7mer-1A | ||||
DVL3 |
7mer-m8 7mer-1A |
||||
EGR1 | 7mer-m8 | ||||
EP300 | *7mer-1A | ||||
FBXW2 | # *7mer-m8 |
8mer* 8mer 7mer-m8 (2) |
|||
FBXW11 | 7mer-m8 # | 7mer-m8 | |||
FGF4 | 7mer-1A* | * | |||
FSHB | 7mer-m8 | 7mer-m8 | 7mer-1A | ||
FZD1 | (*)7mer-m8 | 7mer-m8 | 7mer-1A | ||
FZD2 | 7mer-m8 | ||||
FZD4 | 7mer-m8 | 7mer-1A |
7mer-m8 7mer-1A (2) |
||
FZD5 | 7mer-1A | 7mer-m8 | |||
FZD6 | 7mer-1A | * | 7mer-m8 | ||
FZD8 | 7mer-m8 | ||||
JUN | 8mer | 7mer-m8 # | 8mer | ||
LRP6 | * | 7mer-m8 |
8mer 7mer-1A |
||
MYC | 7mer-1A* | 7mer-1A | |||
NLK |
8mer # 7mer-1A |
||||
NKD1 | 7mer-1A* | 8mer | |||
PLCB1 | # | 7mer-m8 | 7mer-1A | 8mer # 7mer-m8 |
|
PPP2CA | 7mer-m8 # |
7mer-m8 # 7mer-1A |
|||
PPP2R5C | 7mer-1A 7mer-m8 # |
7mer-m8 | 7mer-1A | ||
PPP2R5E |
8mer* 7mer-1A |
7mer-m8 | # | ||
RHOA | 7mer-m8 # | ||||
ROCK2 |
8mer* 7mer-1A 7mer-m8* |
||||
SOX17 | * | 8mer* | |||
TCF4 |
7mer-m8 7mer-1A |
8mer 7mer-m8 7mer-1A |
8mer (2) 7mer-m8 7mer-1A (2) |
7mer-1A (2) | |
VANGL1 | 7mer-m8 (2) | 8mer 7mer-1A |
7mer-1A (3) | ||
VEGF A | 7mer-m8 | 7mer-1A | 8mer* | ||
WIF1 | 8mer* | 7mer-m8 | |||
WNT3A | 7mer-1A | ||||
WNT4 | 7mer-1A | 7mer-m8 | |||
WNT5A | 7mer-m8 | 7mer-m8 | * # | ||
WNT5B | *7mer-m8 | ||||
WNT8A | 7mer-m8 | ||||
WNT16 |
8mer 7mer-m8 |
7mer-m8 |
Note: 8mer: An exact match to positions 2–8 of the mature miRNA (the seed + position 8) followed by an ‘A’, 7mer-m8: An exact match to positions 2–8 of the mature miRNA (the seed + position 8), 7mer-1A: An exact match to positions 2–7 of the mature miRNA (the seed) followed by an ‘A’. Sites in bold indicate that the site is broadly conserved in vertebrates. Parentheses indicate the number of same type sites within the 3′ UTR the gene.
Indicates site predicted by Microcosm,
indicates predicted by PicTar. When symbol appears after TargetScan site, both programs predict the same target.