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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Surg Res. 2010 Feb 11;171(1):218–225. doi: 10.1016/j.jss.2010.01.024

Figure 5.

Figure 5

Administration of exogenous HB-EGF to HB-EGF KO mice reverses the effect of HBEGF gene deletion on intestinal microcirculatory blood flow after HS/R. HB-EGF KO mice were subjected to hemorrhagic shock (MAP maintained at 30–35 mmHg) for 90 minutes followed by reperfusion for 3 hours. Some mice received intra-arterial administration of HB-EGF at the end of the shock period. The intestinal microvasculature was graded using the scoring system described in Figure 1. Compared to HB-EGF KO mice subjected to HS/R, HB-EGF KO mice that received exogenous HB-EGF treatment had more well perfused villi and fewer poorly perfused villi at 3h of resuscitation, indicating that administration of HB-EGF to HB-EGF KO mice improves intestinal microcirculatory perfusion after HS/R.