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. Author manuscript; available in PMC: 2011 Jun 1.
Published in final edited form as: Curr Opin Struct Biol. 2010 Apr 8;20(3):262–275. doi: 10.1016/j.sbi.2010.03.001

Figure 4.

Figure 4

Figure 4

Effects of guanine adducts on DNA conformation. (a) A C2-(2-Naphthyl)-substituted pyrrolo[2,1-c][1,4]benzodiazepines (carbon atoms highlighted in green) covalently attached to G in the duplex [d(AATCTTTAAAGATT)]2 [46] (2k4l; only the underlined portion of the duplex is shown). (b) Trioxacarcin A molecules (carbon atoms highlighted in green) covalently attached to Gs and intercalated into the duplex [d(AACCGGTT)]2, thereby forcing 3′-adjacent Ts into an extra-helical position [52] (3c2j).