Table 3.
Intermediate models showing the influence of the different covariates in the vancomycin parameters
| Model | ΔOF | ωCL (CV%) (RSE) | ωV (CV%) (RSE%) | σ (SD) (RSE%) | |
|---|---|---|---|---|---|
| Basic model | CL =θ1 | – | 50.50 (17.8%) | 83.85 (49.4%) | 4.85 (14.2%) |
| V=θ2 | |||||
| Covariates on CL | |||||
| Age (years) |  |
−8.25 | 49.09 (17.7%) | 82.77 (47.9%) | 4.83 (14.3%) |
| V=θ3 | |||||
| Apache II score |  |
−10.05 | 49.20 (17.7%) | 83.25 (43.6%) | 4.83 (14.4%) |
| V=θ3 | |||||
| Diuretics (Yes/No) | CL =θ1×θ2DIU | −54.90 | 53.85 (15.1%) | 102.47 (32.9%) | 4.45 (12.0%) |
| V=θ3 | |||||
| CLCr (ml min−1 kg−1) | CL =θ1+ CLCr×θ2 | −188.38 | 32.56 (26.9%) | 36.33 (97.0%) | 4.51 (10.8%) |
| V=θ3 | |||||
| Covariates on V | |||||
| Septic shock (Yes/No) | CL =θ1 | −4.27 | 49.80 (16.7%) | 79.31 (38.5%) | 4.82 (13.8%) |
| V=θ2×θ3SOS | |||||
| Apache II score | CL =θ1 | −8.98 | 50.70 (16.8%) | 91.82 (33.1%) | 4.78 (14.4%) |
| V=θ2+ APII ×θ3 | |||||
| CrSe (mg dl−1) A = 1 or 0 if CrSe≥ 1 or <1 | CL =θ1 | −16.60 | 49.09 (16.6%) | 17.66 (79.5%) | 5.04 (13.6%) |
| V=θ2×θ3A | |||||
| Age (years) | CL =θ1 | −20.85 | 47.43 (17.7%) | 77.01 (59.4%) | 4.84 (15.2%) |
| V=θ2×θ3A | |||||
| Fluid balance (ml) | |||||
| B = 1 if positive balance B = 0 if negative balance | CL =θ1 | −42.30 | 52.54 (14.2%) | 100.50 (23.3%) | 4.29 (10.7%) |
| V=θ2×θ3B | |||||
ΔOF, modification in objective function value. ω, interindividual variability expressed as CV%; σ, residual variability expressed as standard deviation. RSE%, relative standard error expressed as a percentage of the variation coefficient.