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. 2010 Aug;70(2):252–257. doi: 10.1111/j.1365-2125.2010.03694.x

Table 1.

Serious drug interactions as identified by at least three drug interaction sources

Interactions considered to be serious by all four references:
Allopurinol and azathioprine
Allopurinol and mercaptopurine
Amiloride and potassium salts
Amiodarone and quinidine
Amiodarone and thioridazine
Cyclosporin and orlistat
Imipramine and clonidine
Itraconazole and pimozide
Lithium and haloperidol
Methotrexate and aspirin
Pravastatin and gemfibrozil
Sildenafil, tadalafil, vardenafil and nitrates
Spironolactone and amiloride
Spironolactone and potassium salts
Triptan and ergot alkaloids
Triptan and monoamine oxidase inhibitors
Verapamil and β-adrenoceptor blockers
Interactions considered to be serious by three references:
Amiloride and ACE inhibitors
Amiloride and tacrolimus
Amiodarone and chlorpromazine
Amiodarone and digoxin
Amiodarone and disopyramide
Amiodarone and haloperidol
Amiodarone and phenothiazines
Amiodarone and sotalol
Atenolol and clonidine
Captopril and potassium salts
Carbamazepine and dextropropoxyphene
Cyclosporin and statins
Diclofenac and heparin
Digoxin and quinidine
Fluoxetine and moclobemide
Fluoxetine and selegiline
Imipramine and entacapone
Imipramine and moclobemide
Itraconazole and quinidine
Itraconazole and simvastatin or atorvastatin
Itraconazole and tacrolimus or sirolimus
Lithium and ACE inhibitor or AIIRB
Llithium and frusemide
Lithium and hydrochlorothiazide
Lithium and phenothiazines
Methotrexate and NSAIDs
Spironolactone and ACE inhibitors
Spironolactone and lithium
Spironolactone and tacrolimus or sirolimus
Tramadol and monoamine oxidase inhibitors
Triptan and methysergide
Triptan and SSRIs
Warfarin and anti-platelet medicines
Warfarin and NSAIDs
Warfarin and miconazole (or other imidazoles)