Skip to main content
. 2009 Aug 28;43(1):88–98. doi: 10.1165/rcmb.2008-0480OC

Figure 4.

Figure 4.

mRNA expression and protein levels of CC and CXC chemokines. Dams were given doxycycline throughout pregnancy and postnatally until the pups were killed at PN7. The IL-1β–induced mRNA expression and protein production of the CXC chemokines, keratinocyte-derived chemokine (KC) (A and B) and macrophage inflammatory protein (MIP)–2 (C and D), were decreased in β6−/− mice. IL-1β increased CXCR2 mRNA expression (E) similarly in β6+/+ and β6−/− mice. Absence of the β6 integrin subunit increased the mRNA expression and protein production of monocyte chemoattractant protein (MCP)–1 (F and G), and the mRNA expression of MCP-3 (H), in both control mice and IL-1β–expressing mice. The mRNA expression levels are shown relative to the mRNA expression level of control/β6+/+ mice, which was set to 1.0. Data are presented as means (±SEM) (n = 7–12 per group). *P < 0.05, **P < 0.01, ***P < 0.001.