TABLE 1.
LACK OF SPONTANEOUS INFLAMMATION IN β6-DEFICIENT MICE AT EMBRYONIC DAY 14
| β6+/+ | β6−/− | |
|---|---|---|
| Macrophages/HPF | 4.86 ± 0.42 | 4.14 ± 0.55 |
| Neutrophils/HPF | 0.64 ± 0.56 | 0.47 ± 0.18 |
| KC mRNA | 0.75 ± 0.22 | 0.70 ± 0.23 |
| MIP-2 mRNA | 0.23 ± 0.04 | 0.36 ± 0.06 |
| MCP-1 mRNA | 1.44 ± 0.05* | 1.19 ± 0.07 |
| MCP-3 mRNA | 0.40 ± 0.02 | 0.36 ± 0.07 |
| Osteopontin mRNA | 0.15 ± 0.02 | 0.19 ± 0.03 |
| S100A8 mRNA | 0.15 ± 0.07 | 0.17 ± 0.04 |
| S100A9 mRNA | 0.10 ± 0.04 | 0.16 ± 0.03 |
| SAA3 mRNA | 0.16 ± 0.07 | 0.37 ± 0.20 |
| Ym1 mRNA | 0.24 ± 0.10 | 0.43 ± 0.13 |
| Ym2 mRNA | 0.35 ± 0.14 | 0.70 ± 0.20 |
Definition of abbreviations: HPF, high-power field; KC, keratinocyte-derived chemokine; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; S100A8, calgranulin A; S100A9, calgranulin B; SAA3, serum amyloid A3.
mRNA expression of inflammatory genes (relative to β-actin) (n = 8–12). For macrophage and neutrophil counts, four to eight animals per group were studied. Data are shown as means (±SEM).
*
P < 0.01 versus β6-deficient mice. All other differences are not significant.