TABLE I.
Inflammatory lesions of tissues in raccoons experimentally infected with Trypanosoma cruzi via different routes. Inoculation methods were as follows: group 1 intravenously (i.v.) with 1 × 106 culture-derived trypomastigotes; groups 2, 3, and 4 per os (p.o.) with 33.3 g of amastigote-infected tissue at 2, 12, and 24 hr post-mortem, respectively; group 5 p.o. with 3 infected R. prolixis fourth or fifth instar nymphs; and group 6 p.o. with 1 × 106 culture-derived trypomastigotes.
Animal | Tissue |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
LN* | Skeletal muscle | Heart | Lung | Liver | Spleen | GI* | Pancreas | Adrenal gland | Kidney | Bladder | Sex organ | Brain | |
Group 1 (i.v.) | |||||||||||||
RAC A | Vm* | S*† | S† | S | Mo* | Vm | Vm | M*† | M† | Vm | M | M | M |
Group 2 (2 hr) | |||||||||||||
RAC B | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm |
RAC C | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm |
Group 3 (12 hr) | |||||||||||||
RAC D | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm |
RAC E | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm |
Group 4 (24 hr) | |||||||||||||
RAC F | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm |
RAC G | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm |
Group 5 (bug) | |||||||||||||
RAC H | Vm | M | Mo | Vm | S | Vm | Vm | Vm | Vm | Vm | Mo | Vm | Vm |
RAC I | Vm | M | Mo† | Vm | S | Vm | Vm | Vm | Vm | Vm | Vm | Vm | Vm |
Group 6 (p.o. control) | |||||||||||||
RAC J | Vm | Mo | M | Vm | Mo | Vm† | Vm | Vm | S | M | Vm | M | Vm |
LN, lymph node; GI, gastrointestinal tract; Vm, very mild; M, mild; Mo, moderate; S, severe.
Pseudocyst(s) found within tissue sample.