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. Author manuscript; available in PMC: 2011 Jul 23.
Published in final edited form as: Cell. 2010 Jul 23;142(2):320–332. doi: 10.1016/j.cell.2010.06.020

Figure 2. SIRT1 improves the behavioral phenotype of Alzheimer's Disease mouse model.

Figure 2

(A) Schema of the fear conditioning experiment. (B) The graph shows the total percentage of freezing (on day 2) of the wt, Tg, AD and AD-Tg mice of the indicated ages across the entire 5-min tone retrieval test. n=10-15 for each bar. (C) The graph shows the total percentage of freezing of the wt, BSKO, AD and AD-BSKO mice at 4 months of age across the entire 5-min tone retrieval test. n=10-15 (D) Morris water maze experiment (D-F). Escape latency (time to find the platform) was plotted for 7 days for 11, 8 and 4 months old of AD and AD-Tg mice. n= 6-12 (E) Escape latency plotted over 7 days for 11, 8 and 4 months old of Tg and wt mice. n=6-12 (F) Escape latency plotted over 7 days for 4 months old of wt, BSKO, AD and AD-BSKO mice. n=6-12 (see also Figure S1)