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. Author manuscript; available in PMC: 2011 Aug 1.
Published in final edited form as: Am J Transplant. 2010 Aug;10(8):1738–1748. doi: 10.1111/j.1600-6143.2010.03161.x

Figure 5. LCMV-specific CD8 T cells mediate rejection of skin allografts.

Figure 5

B6/SJL mice (CD45.1) were infected with LCMV and 8 days later spleens were harvested and pooled. (A) Splenocytes were stained with NP396-MHC tetramers and with mAb to CD8, and double positive cells were purified by sorting. The purity of NP396-tetramer positive cells is shown as the percentage of total cells and as the percentage of CD8 T cells (values in parentheses). (B) Purified NP396-specific CD8 T cells (1–2×106 cells) were then adoptively transferred into B6/SCID mice bearing BALB/c skin grafts. (C) Skin graft survival was monitored over the next 100 days. The data are representative of 2 experiments.