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. 2010 Jul 12;190(1):35–43. doi: 10.1083/jcb.201004017

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© 2010 Rankin and Wordeman

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Figure 1. — MCAK depletion causes severe anaphase spindle rocking. (A) A HeLa cell stably expressing EGFP–α-tubulin and treated with MCAK-specific siRNA for 36 h exhibiting severe spindle rocking. Time is relative to anaphase onset. Asterisks mark location of chromosomes. Bar, 5 µm. (B) Quantification of cells filmed exhibiting spindle rocking. MCAK depletions had significantly more severe spindle rocking than controls (P < 0.0001). Weak rocking was defined as movement of the spindle along the spindle axis without either set of chromosomes moving through the cleavage furrow. Severe spindle rocking was scored when the chromosomes moved through the cleavage furrow at least once. Error bars indicate SEM.