Figure 1.

Methodological aspects of strict glycemic control, which may contain potential sources of variability in the performance of this strategy. Items are categorized into the following subjects: 'monitoring', 'insulin delivery', 'algorithm', and 'experience'. Items are also roughly positioned on a line from 'easy', 'simple', 'distinct' and/or 'clear' to implement towards 'obscure', 'indistinct', 'complex' and/or 'difficult' to translate from one center to another. Specific elements per item indicated with an asterisk are as performed in the single-center RCTs from Leuven. SGC, strict glycemic control.