Table 1.
Distribution of genotypes in the patients and healthy controls
| Genotype | TIRAP/Mal | |||||
|---|---|---|---|---|---|---|
| Wild type | heterozygous | Homozygous | ||||
|
Group I (n = 375) |
Wild type | 240 (64.0%) | 75 (20.0%) | 10 (2.7%) | AF TIRAP/Mal: 0.140 |
|
| TLR4 | heterozygous | 41 (10.9%) | 7 (1.9%) | 1 (0.3%) | ||
| homozygous | -- | 1 (0.3%) | -- | |||
| AF TLR4: 0.068 |
||||||
| Wild type | heterozygous | Homozygous | ||||
|
Group II (n = 159) |
Wild type | 106 (66.7%) | 40 (25.2) | 1 (0.6 %) | AF TIRAP/Mal: 0.142 |
|
| TLR4 | heterozygous | 9 (5.7%) | 3 (1.9%) | -- | ||
| homozygous | -- | -- | -- | |||
| AF TLR4: 0.038 |
||||||
| Wild type | heterozygous | Homozygous | ||||
|
Group III (n = 415) |
Wild type | 254 (61.2%) | 89 (21.4%) | 7 (1.7%) | AF TIRAP/Mal: 0.151 |
|
| TLR4 | heterozygous | 45 (10.8%) | 14 (3.4%) | 4 (1.0%) | ||
| homozygous | 2 (0.5%) | -- | -- | |||
| AF TLR4: 0.080 |
||||||
| Wild type | heterozygous | Homozygous | ||||
| Controls (n = 176) | Wild type | 122 (69.3%) | 26 (14.8%) | 2 (1.1%) | AF TIRAP/Mal: 0.102 |
|
| TLR4 | heterozygous | 20 (11.4%) | 3 (1.7%) | 1 (0.6%) | ||
| homozygous | 1 (0.6%) | 1 (0.6%) | -- | |||
| AF TLR4: 0.080 |
||||||
Allele frequencies equal between the groups. All groups in Hardy-Weinberg-Equilibrium: For TLR4: Group 1: P = 0.55; Group II: P = 0.62; Group III: P = 0.64; Controls: P = 0.36. For TIRAP/Mal: Group 1: P = 0.12; Group II: P = 0.40; Group III: P = 0.54; Controls: P = 0.34.
AF, allelic frequency, Mal, MyD88-adaptor-like, MyD88, myeloid differentiation response factor 88, TIR, toll/interleukin-1 receptor, TIRAP, TIR-associated protein, TLR, toll-like receptor.