Table 2.
Association between septic complications and genotype in 375 patients of Group I
| Genotype | Severe Infections (n = 102) | aOR | 95% CI | P value |
|---|---|---|---|---|
|
Wild-type (n = 240) |
64 (26.7%) | 0.87 | 0.51 - 1.48 | 0.69 |
| Mutant alleles | ||||
| TLR4 (n = 41) | 10 (24. 4%) | 1.57 | 0.73 to 3.37 | 0.33 |
|
TIRAP (het) (n = 75) |
15 (20.0%) | 0.87 | 0.49 to 1.56 | 0.65 |
| TIRAP (hom) (n = 10) | 7 (70.0%) | 7.33 | 1.89 to 28.50 | < 0.01 |
| TIRAP/TLR4 genotype (n = 9) | 6 (66.7%) | 5.50 | 1.34 to 22.64 | 0.02 |
aOR (odds ratio) when comparing severe infections (severe sepsis and septic shock) to patients with no infection. Calculated by comparison of wild type-patients with patients bearing other variants through Mantel-Haenzel's statistic and Fisher's exact test.
CI, confidence interval, het, heterozygous, hom, homozygous, Mal, MyD88-adaptor-like, MyD88, myeloid differentiation response factor 88, OR, odds ratio, TIR, toll/interleukin-1 receptor, TIRAP, TIR-associated protein, TLR, toll-like receptor.