Table 2.
Changes over the four study periods
| Variable | 1996 to 1997 (n = 24, 8.5%) | 1998 to 2000 (n = 76, 26.8%) | 2001 to 2003 (n = 91, 32%) | 2004 to 2005 (n = 93, 32.7%) | P value |
|---|---|---|---|---|---|
| Mean age (years) | 35 (30 to 41) | 40 (35 to 48) | 43 (36 to 49) | 44 (40 to 50) | 0.0002 |
| African ethnicity | 6 (25) | 11 (14.5) | 26 (28.6) | 34 (36.6) | 0.01 |
| Co-morbidities | |||||
| Hepatic cirrhosis | 1 (4.2) | 11 (14.5) | 10 (11) | 6 (6.4) | 0.24 |
| Chronic hepatitis C infection | 2 (8.3) | 19 (25) | 23 (25.3) | 12 (12.9) | 0.03 |
| Chronic hepatitis B infection | 3 (12.5) | 16 (21) | 15 (16.5) | 16 (17.2) | 0.76 |
| Homeless | 0 | 4 (5.3) | 8 (8.8) | 14 (15) | 0.05 |
| HIV-related characteristics | |||||
| Time from diagnosis (months) | 46 (2 to 125) | 70 (3 to 147) | 74 (6 to 135) | 81 (6 to 170) | 0.42 |
| HAART administrationa | 9 (37.5) | 40 (52.6) | 52 (57.1) | 49 (52.7) | 0.39 |
| New HIV diagnosisb | 6 (25) | 17 (22.4) | 18 (20.2) | 15 (17) | 0.77 |
| CD4+ cell count >200/mm3 | 6 (26.1) | 26 (35.1) | 23 (27.7) | 30 (36.1) | 0.55 |
| Direct admission to the ICU | 16 (66.7) | 31 (40.8) | 40 (44) | 44 (47.3) | 0.15 |
| Main reason for ICU admissions | |||||
| Sepsis | 7 (29.2) | 15 (19.7) | 23 (25.3) | 23 (24.7) | 0.74 |
| Bacterial pneumonia | 7 (29.2) | 25 (32.9) | 32 (35.2) | 30 (32.3) | 0.94 |
| Pneumocystis pneumonia | 4 (16.7) | 17 (22.4) | 14 (15.4) | 18 (19.3) | 0.69 |
| Cerebral toxoplasmosis | 1 (4.2) | 4 (5.3) | 5 (5.5) | 6 (6.4) | 0.97 |
| SAPS II | 53 (33 to 60) | 44 (31 to 57) | 46 (32 to 55) | 48 (35 to 61) | 0.44 |
| Life-supporting procedures | |||||
| Mechanical ventilation | 14 (58.3) | 38 (50) | 40 (44) | 32 (34.4) | 0.08 |
| Renal replacement therapy | 3 (12.5) | 8 (10.5) | 13 (14.3) | 7 (7.5) | 0.52 |
| Vasopressors | 8 (33.3) | 18 (23.7) | 21 (23) | 17 (18.3) | 0.46 |
| ICU mortality | 6 (25) | 13 (17.1) | 12 (13.2) | 8 (8.6) | 0.01 |
Data presented as median (interquartile range) or number (percentage). HAART, highly active antiretroviral therapy; ICU, intensive care unit; SAPS II, Simplified Acute Physiological Score version II. aHAART administration prescribed for more than 30 days before ICU admission. bDiagnosis of HIV infection within past 60 days.