Table 3.
Perioperative period ('per protocol' analysis)
| Parameters | Vigileo group | Control group | P value |
|---|---|---|---|
| n = 51 (85%) | n = 54 (90%) | ||
| Baseline measurement | |||
| MAP (mmHg) | 103 ± 13 | 103 ± 16 | 0.948 |
| CVP (mmHg) | 8 ± 2 | 9 ± 4 | 0.362 |
| HR (beats/min) | 74 ± 13 | 74 ± 10 | 0.851 |
| CI (ml/min/m2) | 3 ± 0.64 | N/A | |
| SVV (%) | 13 ± 5 | N/A | |
| End of surgery | |||
| MAP (mmHg) | 92 ± 12* | 91 ± 14* | 0.702 |
| CVP (mmHg) | 10 ± 3* | 10 ± 3 | 0.439 |
| *(P = 0.0002 vs. baseline) | |||
| HR (beats/min) | 70 ± 11* | 73 ± 15 | 0.264 |
| *(P = 0.0108 vs. baseline) | |||
| CI (ml/min/m2) | 3.6 ± 0.7* | N/A | |
| *(P < 0.0001 vs. baseline) | |||
| SVV (%) | 7 ± 2* | N/A | |
| *(P < 0.0001 vs. baseline) | |||
| Number of hypotensive periods intraoperatively | 2 (1-2) | 3.5 (2-6) | 0.0001 |
| Length of anesthesia (min) | 184 ± 46 | 202 ± 53 | 0.072 |
| Length of surgery (min) | 163 ± 44 | 176 ± 55 | 0.214 |
| Length of aortic cross-clamping | 61.5 ± 35 | 57 ± 35 | 0.592 |
| Crystalloids (ml) | 2321 ± 681 | 2459 ± 930 | 0.386 |
| Colloids (ml) | 1425 (1000-1500) | 1000 (540-1250) | 0.0028 |
| Blood (ml) | 0 (0-566) | 270 (0-578) | 0.633 |
| Fresh frozen plasma (ml) | 0 (0-540) | 0 (0-540) | 0.793 |
| Estimated blood loss (ml) | 700 (500-1200) | 800 (400-1325) | 0.511 |
| Diuresis (ml/kg/h) | 1.13 (0.76-1.85) | 0.896 (0.56-1.43) | 0.068 |
| Norepinephrine | 3 (5.88%) | 11 (20.37%) | 0.058 |
| Dobutamine | 2 (3.92%) | 0 (0%) | 0.451 |
| Vasodilatation therapy | 5 (9.8%) | 3 (5.56%) | 0.652 |
| After eight hours on ICU | |||
| Crystalloids (ml) | 1587 ± 371 | 1528 ± 475 | 0.485 |
| Colloids (ml) | 0 (0-500) | 0 (0-250) | 0.887 |
| Blood (ml) | 0 (0-0) | 0 (0-0) | 0.746 |
| Fresh frozen plasma (ml) | 0 (0-0) | 0 (0-0) | 0.744 |
| Diuresis (ml/kg/h) | 1.18 (0.79-1.89) | 1.08 (0.83-1.89) | 0.886 |
| Norepinephrine | 7 (13.72%) | 6 (11.11%) | 0.913 |
| Dobutamine | 1 (1.96%) | 0 (0%) | 0.977 |
| Vasodilatation therapy | 10 (19.61%) | 9 (16.67%) | 0.891 |
| Diuretic support | 13 (25.49%) | 17 (31.48%) | 0.643 |
| SOFA (8 hours) | 3 (2-5.25) | 3 (1-4) | 0.474 |
| SOFA (24 hours) | 2 (2-4) | 3 (1.5-4) | 0.541 |
Perioperative period analyzed only for patients whose intraoperative protocol was carried in full extent. Values are presented as absolute (percentage), mean ± standard deviation or median (interquartile range).
CI, cardiac index; CVP, central venous pressure; HR, heart rate; MAP, mean arterial pressure; N/A, not applicable; SOFA, Sequential Organ Failure Assessment; SVV, stroke volume variation.