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Contrast CT (left), micro-SPECT (center), and fused SPECT/CT (right) images of apoEā/ā mice fed Western diet for more than 16 wk. Imaging showed no focal aortic arch hot spots in mice injected with a nonspecific IgG antibody (nIgG) probe (top row), whereas all mice injected with targeted LOX-1 probe had hot spots in aortic arch (lower row). Results were confirmed by ex vivo phosphor imaging of excised aortas. Sudan IV staining demonstrated comparable plaques between the 2 groups.
