Figure 4. Gpx2 deficiency enhances allergic airway inflammation and airway reactivity.
Compared with WT littermates (wt, n=6), Gpx2 KO mice (n=6) showed increased airway inflammation, due to an increased influx of eosinophils and lymphocytes after sensitization and challenge with antigen. (A). OVA-spec. IgE and IgG1 were increased in Gpx-2 KOmice but to a significant level (B, C). Comparing airway resistance in isolated perfused lungs of Gpx2 KO and wild type mice (n= 6 each) after sensitization and challenge, we found a higher relative fold airway resistance in Gpx2 KO mice than in the corresponding WT controls (D).
* P < 0.05