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. Author manuscript; available in PMC: 2010 Jul 29.
Published in final edited form as: Eur Respir J. 2009 Nov 6;35(5):1148–1154. doi: 10.1183/09031936.00026108

Figure 4. Gpx2 deficiency enhances allergic airway inflammation and airway reactivity.

Figure 4

Compared with WT littermates (wt, n=6), Gpx2 KO mice (n=6) showed increased airway inflammation, due to an increased influx of eosinophils and lymphocytes after sensitization and challenge with antigen. (A). OVA-spec. IgE and IgG1 were increased in Gpx-2 KOmice but to a significant level (B, C). Comparing airway resistance in isolated perfused lungs of Gpx2 KO and wild type mice (n= 6 each) after sensitization and challenge, we found a higher relative fold airway resistance in Gpx2 KO mice than in the corresponding WT controls (D).

* P < 0.05

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