Figure 6.

Histopathology of BALB/c heart transplants from dm2 mice sensitized with L^d 61–80 peptide emulsified in IFA. dm2 mice were immunized i.p. with L^d 61–80 MHC class I peptide emulsified in IFA. Ten days later, these mice received a heart transplant from a BALB/c donor. (A, B) Histology of BALB/c heart transplants from control unimmunized dm2 mice. (C, D) Photomicrographs (40×) of allogeneic hearts harvested 50 and 100days post-transplantation from a L^d 61–80-sensitized recipient mouse display a lymphocytic inflammatory cell infiltrate and vessel obstruction. Data are representative of eight mice tested individually.