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. 2010 May 18;12(3):R92. doi: 10.1186/ar3019

Figure 4.

Figure 4

Oral administration of ZSTK474 ameliorated CIA in mice. In vitro effect of ZSTK474 was examined in mice CIA. On Day 28, when half of the mice had developed arthritis, oral administration of ZSTK474 was commenced once a day. a) Arthritis scores were compared among the groups. b) Synovial tissues from the hindpaws of vehicle-treated CIA mice, 50 mg ZSTK474-treated CIA mice and normal age-matched DBA mice were stained with hematoxylin and eosin (H&E) or with safranin O. Representative results are shown. c) In the therapeutic protocol, 100 mg/kg of ZSTK474 was started on Day 31, when all mice had developed arthritis.