Table 2.
PBMC subpopulations for which significant differences existed between the controls, patients with JIA other than sJIA, and patients with systemic arthritis
| PBMC subpopulation | Percentage of PBMC | Pairwise multiple comparison | |||||
|---|---|---|---|---|---|---|---|
| 1. Controls | 2. non-sJIA | 3. sJIA | ANOVA | 1. vs. 2. | 1. vs. 3. | 2. vs. 3. | |
| CD3-CD56+ | 6.1 ± 3.9 | 7.4 ± 4.0 | 4.7 ± 1.7 | 0.02 | NS | NS | < 0.05 |
| CD56+ dim | 5.5 ± 3.5 | 6.7 ± 3.9 | 3.7 ± 1.4 | 0.009 | NS | NS | < 0.05 |
| CD15+CD16- | 0.05 ± 0.03 | 0.06 ± 0.05 | 0.18 ± 0.19 | < 0.001 | NS | < 0.05 | < 0.05 |
| CD8+CD25+ | 0.46 ± 0.26 | 0.78 ± 0.60 | 0.70 ± 0.40 | 0.005 | < 0.05 | NS | NS |
| CD19+ | 16.8 ± 6.6 | 13.2 ± 5.8 | 11.7 ± 6.6 | 0.002 | < 0.05 | < 0.05 | NS |
| CD34+ | 0.08 ± 0.04 | 0.08 ± 0.05 | 0.16 ± 0.11 | < 0.001 | NS | < 0.05 | < 0.05 |
| CD34+CD33- | 0.05 ± 0.03 | 0.06 ± 0.04 | 0.11 ± 0.09 | < 0.001 | NS | < 0.05 | < 0.05 |
| CD34+CD33+ | 0.03 ± 0.02 | 0.02 ± 0.02 | 0.05 ± 0.03 | < 0.001 | < 0.05 | NS | < 0.05 |
| NK bright/dim ratio | 0.14 ± 0.09 | 0.13 ± 0.12 | 0.28 ± 0.16 | < 0.001 | NS | < 0.05 | < 0.05 |
| CD4:CD8 ratio | 2.20 ± 0.7 | 2.14 ± 0.7 | 2.81 ± 0.9 | 0.006 | NS | < 0.05 | < 0.05 |
Differences were analyzed with one-way ANOVA followed by Tukey's pairwise multiple comparison, assuming a significance level of P < 0.05. PBMCs, peripheral blood mononuclear cells; JIA, juvenile idiopathic arthritis; sJIA, systemic JIA; non-sJIA, JIA other than sJIA.