. Author manuscript; available in PMC: 2010 Aug 1.

Published in final edited form as: Nutr Cancer. 2010 Aug;62(6):811–824. doi: 10.1080/01635581003693082

TABLE 1.

Comparison of antiproliferative potencies of curcumin, carnosic acid, silibinin alone vs. combinations on the basis of IC₅₀ values (in μM)

No.	Polyphenol	HL60 cells			KG-1a cells
		Alone	+10 μM CA	+30 μM SIL	Alone	+10 μM CA	+30 μM SIL
1	Curcumin	6.79±0.53	1.20±0.12^**	4.37±0.54^*	6.19±0.57	1.41±0.087^**	4.56±0.29^*
			*+5 μM CUR*			*+5 μM CUR*
2	Carnosic acid	16.80±0.97	0.86±0.18^***		27.30±1.40	0.95±0.17^***
			*+5 μM CUR*			*+5 μM CUR*
3	Silibinin	62.55±4.44	37.35±2.57^**		55.54±3.84	27.66±2.99^*

The IC₅₀ values presented in rows 1, 2 and 3 were calculated by nonlinear regression analysis from the dose-response curves shown in Figs. 1A, 1B and 1C, respectively.

(P < 0.05)

^**

(P < 0.01)

^***

(P < 0.001), significant differences between the effects of an agent alone and its combination with another agent.

CUR, curcumin; CA, carnosic acid; SIL, silibinin.