Table 4.
Levels of plasma tumour necrosis factor-α and interleukin-6 in rats after the induction of pancreatitis
| Group; factor | Time; cytokine level, pg/mL | ||
|---|---|---|---|
| 3 h | 6 h | 10 h | |
| TNF-α n = 15 | |||
| Group 1: Control | 10.28 (2.06) | 13.33 (2.13) | 10.46 (2.05) |
| Group 2: Sham surgery | 22.68 (3.56) | 25.75 (5.31) | 27.57 (6.58) |
| Group 3: ANP with no treatment | 92.93 (21.90) | 269.67 (35.64) | 329.16 (23.11) |
| Group 4: ANP with HBO | 75.96 (5.36) | 219.29 (9.37) | 262.76 (12.39) |
| Group 5: ANP with ulinastatin | 65.61 (7.71) | 189.29 (8.17) | 278.19 (23.15) |
| Group 6: ANP with HBO and ulinastatin | 34.33 (5.59)*† | 55.42 (8.21)*† | 64.34 (9.63)*† |
| IL-6, n = 15 | |||
| Group 1: Control | 67.2 (8.8) | 58.8 (6.9) | 64.8 (7.6) |
| Group 2: Sham surgery | 158 (12.5) | 179.8 (13.6) | 212.8 (19.4) |
| Group 3: ANP with no treatment | 793.9 (98.9) | 935.93 (82.9) | 1136.93 (96.6) |
| Group 4: ANP with HBO | 592.68 (53.2) | 735.6 (75.3) | 875.2 (68.8) |
| Group 5: ANP with ulinastatin | 628.6 (73.7) | 825.6 (95.3) | 877.6 (86.7) |
| Group 6: ANP with HBO and ulinastatin | 347.8 (13.9)*† | 357.5 (15.5)*† | 428.7 (25.4)*† |
ANP = acute necrotizing pancreatitis; ENC = endotoxin-neutralizing capacity; HBO = hyperbaric oxygen; IL= interleukin; TNF = tumour necrosis factor.
*
Significantly different from group 3 (p < 0.05).
†
Significantly different from groups 4 and 5 (p < 0.05).