F	Feasible	Adequate number of subjects Adequate technical expertise Affordable in time and money Manageable in scope
I	Interesting	Getting the answer intrigues investigator, peers and community
N	Novel	Confirms, refutes or extends previous findings
E	Ethical	Amenable to a study that institutional review board will approve
R	Relevant	To scientific knowledge To clinical and health policy To future research

Adapted with permission from Wolters Kluwer Health.²