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(A) Accumulation of intraneuronal Aβ42 at early stages of AD occurs progressively in a synapse (left) and is associated with pathological alterations compared to a normal synapse (right). (B) Intraneuronal Aβ42 is released in the extracellular space following degeneration of the synapse (left). Release of intraneuronal Aβ42 into the extracellular space may contribute to the toxic spread of Aβ pathology to a nearby synapse (right).
