TABLE 2.
Pharmacokinetic parameters for intraperitoneally administered BaP in IE-Cpr-null, liver-Cpr-null, and WT mice
Data from Fig. 2 were analyzed for determination of pharmacokinetics parameters. Values represent means ± S.D. (n = 6–8).
| Experiment No. | Strain | Tmax | Cmax | t1/2 | AUC0-6 h | 
|---|---|---|---|---|---|
| h | ng/ml | h | ng · h/ml | ||
| 1 | WT | 0.50 | 115 ± 27 | 3.44 ± 1.18 | 309 ± 64 | 
| IE-Cpr-null | 0.56 | 119 ± 27 | 2.91 ± 1.05 | 297 ± 39 | |
| 2 | WT | 0.50 | 128 ± 36 | 3.06 ± 0.52 | 336 ± 73 | 
| liver-Cpr-null | 0.56 | 114 ± 21 | 2.23 ± 0.30** | 355 ± 52 | 
P < 0.01, compared with the WT group (Student's t test).