TABLE 5.
Pentobarbital clearance in B6, r-CL, and xh-CL mice
Male mice (2 to 3 months old) were treated with pentobarbital (10 mg/ml in phosphate-buffered saline) at a dose of 60 mg/kg i.p.. The lengths of time between drug administration and the loss and the subsequent recovery of righting reflex were recorded. Values presented are means ± S.D. The numbers of animals examined in each group are shown in parentheses.
| Strain | Onset of Sleep | Sleep Duration |
|---|---|---|
| min | ||
| B6 (n = 6) | 4.1 ± 0.7 | 68 ± 8 |
| r-CL (n = 5) | 4.4 ± 0.8 | 278 ± 47a |
| xh-CL (n = 6) | 4.2 ± 0.5 | 66 ± 12 |
a
Significantly greater than the B6 group or the xh-CL group; P < 0.01 (Student's t test).