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Concentration-response relationship for morphine-induced decrease in basal Isc. Morphine or 0.9% NaCl (control) was applied to the submucosal side of the chamber, and changes in basal Isc were evaluated after 10 min. Morphine decreased the basal Isc in a concentration-dependent manner, with an IC50 value of 96.1 nM. Values are expressed as means ± S.E.M., with n = 4 preparations from each of six animals.
