TABLE 1.
Pharmacokinetics of oral BaP in the four genotypes, after gavage
Values are expressed as means ± S.E.M. (n = 4). P values (shown in parentheses) represent comparisons to the mean values of Cyp1a1(f/f) mice (calculated using Student's t test, two-tailed). In every case, the time needed to achieve Cmax, the maximum concentration reached in the blood, was 90 min.
| Genotype | AUC | CL | t½ | Cmax |
|---|---|---|---|---|
| min · μg/ml | ml/min · kg | min | ng/ml | |
| Cyp1a1(f/f) | 71.3 ± 2.6 | 208 ± 8.0 | 47.7 ± 1.8 | 636 ± 26 |
| Alb>Cre>Cyp1a1(−/−) | 101 ± 3.9 (8.3 × 10−4) | 148 ± 5.4 (1.0 × 10−3) | 48.3 ± 2.7 (0.82) | 919 ± 32 (9.5 × 10−4) |
| Vil>Cre>Cyp1a1(−/−) | 146 ± 1.3 (5.2 × 10−5) | 103 ± 0.92 (7.4 × 10−4) | 79.1 ± 7.3 (0.034) | 810 ± 10 (0.0068) |
| Cyp1a1(−/−) | 233 ± 2.4 (4.2 × 10−5) | 63.3 ± 0.70 (4.3 × 10−4) | 92.9 ± 3.7 (0.0028) | 778 ± 52 (0.076) |