AMPH-induced SWIP requires DAT-1. A, AMPH treatment induces a time- and concentration-dependent increase in SWIP (solid symbols). In contrast, vehicle treatment (□) does not induce paralysis (*, p < 0.01, one-way analysis of variance). B, in dat-1 animals, AMPH treatment (100 μM at 4 min; ●) did not induce a significant increase in SWIP with respect to vehicle treated animals (□). Inset, ΔSWIP calculated after treatment for 4 min with 100 μM AMPH for wt (n = 15, 271 animals) and dat-1 animals (n = 8, 136 animals).