Fig. 2.

AMPH-induced SWIP is supported by CAT-2, CAT-1, DOP-2, DOP-3, and DOP-4 expression. AMPH-induced ΔSWIP was significantly (Student's t test) diminished in A animals lacking tyrosine hydroxylase (A; *, p < 0.01; n = 6, 121 animals), VMAT (B; *, p < 0.05; n = 11, 163 animals), DOP-2 (D; *, p < 0.05; n = 14, 206 animals), DOP-3 (E; *, p < 0.005; n = 8, 151 animals), and DOP-4 (F; *, p < 0.005; n = 4, 106 animals) receptors compared with wt animals (dotted line). In contrast, AMPH-induced SWIP (C) was not significantly reduced in worms lacking DOP-1 (n = 12; 228 animals). All data are expressed as a percentage of wt.