TABLE 1.
A nonexhaustive list of G proteins coupling to RTKs and their functions
| RTK | G Proteins | Functions | References |
|---|---|---|---|
| EGFR | Gαi1/i2 | Inhibition of adenylyl cyclase | Stryjek-Kaminska et al., 1996 |
| Gαi/o | Activation of PLC | Liang and Garrison, 1991 | |
| Gαi1/i3/(i2?) | Activation of Akt-mTORC1 pathway | Cao et al., 2009 | |
| Gαs | Activation of adenylyl cyclase | Nair et al., 1990 | |
| FGFR | Gαs | Activation of adenylyl cyclase | |
| Gβγ | Inhibition of NADPH oxidase | Krieger-Brauer et al., 2000 | |
| Insulin receptor | Gαi/o | ||
| Gαq/11 | |||
| Gαi2 | Activation of NADPH oxidase | Krieger-Brauer et al., 1997 | |
| IGF-IR | Gαi | ||
| Gβγ | Luttrell et al., 1995 | ||
| IGF-IIR | Gαi/o | Ca2+ influx and DNA synthesis | Okamoto et al., 1990 |
| CSF-1R | PKC and Na+ influx | Imamura et al., 1990; Corre and Hermouet, 1995 |
FGFR, fibroblast growth factor receptor; CSF-1R, colony stimulating factor 1 receptor.