TABLE 2.
A partial list of non-7TMR proteins that physically and/or functionally couple to the G12 subfamily
| Proteins | G Proteins | Functions | References |
|---|---|---|---|
| Cadherins | Gα12/13 | Release of β-catenin for transcriptional activation; regulation of epiboly | Kaplan et al., 2001; Meigs et al., 2001; Lin et al., 2009 |
| Factor VIIa/TF (tissue factor) | Gα12/13 | Jak2 activation, Jak2/STAT5-dependent production of Bcl(XL) | Versteeg et al., 2004 |
| Hax-1 | Gα13 | Gα13 forms complex with Hax-1, Rac and cortacin for cell movement | Radhika et al., 2004 |
| Integrin aIIbβ3 | Gα13 | Integrin signaling, platelet adhesion | Gong et al., 2010 |
| Hsp90 | Gα12 (not Gα13) | Localization of Gα12 to lipid rafts | Waheed and Jones, 2002 |
| PP2A | Gα12 | Increase in PP2A phosphatase activity | Zhu et al., 2004 |
| PP5 | Gα12/13 | Gα12/13 interact with TPR domain in PP5, increasing its phosphatase activity | Yamaguchi et al., 2002 |
| Radixin | Gα13 | Conformational activation of radixin and its binding to polymerized F-actin | Vaiskunaite et al., 2000 |
| RTK | Gα13 (not Gα12) | Necessary for PDGF-induced cell migration | Shan et al., 2006 |
| Socius | Gα12/13 | Gα12/13-dependent RhoA activation | Tateiwa et al., 2005 |
PP2A, protein phosphatase 2A; PP5, protein phosphatase 5.