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. 2010 Aug;136(2):179–187. doi: 10.1085/jgp.201010444

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© 2010 Martínez-François et al.

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Figure 11. — Analysis of voltage gating produced by lowering pH_o. (A and B) Schemes representing gating of the CNGA1 channel, in which C and C_L represent closed channel states without and with cGMP bound, respectively, whereas O₁ and O₂ are two sequential open states in voltage-sensitive equilibrium. (C) Normalized G-V relations (mean ± SEM; n = 5) between 10 and 200 mV for CNGA1 channels at the indicated pH_o. Curves correspond to a simultaneous fit of Eq. 2 to all datasets with K₂ and Z_K2 common to all curves. Best-fit parameters were (common) K₂ = 0.38 ± 0.10 and Z_K2 = 0.52 ± 0.03, and individual K₁ values at each pH_o (listed in Table I). (D) K₁ plotted against pH_o. Curve is a fit of a binding isotherm yielding apparent pKa = 6.2 ± 0.4.