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. 2010 Aug;136(2):179–187. doi: 10.1085/jgp.201010444

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© 2010 Martínez-François et al.

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Figure 2. — Extracellular protons render the CNGA1 channel voltage sensitive in phosphate-buffered solutions. (A–F) Macroscopic current traces at the indicated pH_o and fixed pH_i 8, recorded in symmetric 130 mM Na⁺ and 2 mM of intracellular cGMP from inside-out patches containing CNGA1 channels. (G) I-V curves (mean ± SEM; n = 5) at the indicated pH_o, each normalized to the current at 200 mV. (H) Corresponding normalized G-V curves (mean ± SEM; n = 5).