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. 2010 Aug;136(2):179–187. doi: 10.1085/jgp.201010444

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© 2010 Martínez-François et al.

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Figure 3. — Current inhibition by extracellular protons. Fraction of current relative to that at pH_o 8 (I/I_pH8; mean ± SEM; n = 5), plotted against pH_o for 50 mV (open circles) and −50 mV (filled circles). Curves are Hill equation fits with a common coefficient (n) yielding IC₅₀ = 4.9 ± 1.2 × 10⁻⁷ M at −50 mV (pK_a = 6.3), IC₅₀ = 2.9 ± 0.7 × 10⁻⁶ M at 50 mV (pK_a = 5.5), and n = 0.66 ± 0.06.