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. 2010 Aug;136(2):179–187. doi: 10.1085/jgp.201010444

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© 2010 Martínez-François et al.

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Figure 5. — Effect of D₂O on CNGA1 current at pH_o 4. (A and B) Macroscopic currents at pH_o 4 (A) and corresponding G-V curve (B; mean ± SEM; n = 4) for the wild-type CNGA1 channel in D₂O solutions. (C) Current transients elicited by stepping membrane voltage from −80 to 180 mV in D₂O (from A; black) or H₂O (from Fig. 2 F; red). The superimposed curves are single-exponential fits. (D) Time constant (mean ± SEM; n = 4) for current activation at 180 mV (τ_180mV) in D₂O and H₂O solutions obtained from fits as shown in C.