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Peptide dissociation rates for mutant DR1 moleculesa
| DM (nM) |
||||||
|---|---|---|---|---|---|---|
| 0 | 250 | 500 | 1000 | 2000 | n | |
| DR1 (HA) | 1.9 x 10−7 | 8.2 x 10−7 | 1.2 x 10−6 | 2.0 x 10−6 | 3.7 x 10−6 | 3 |
| N82A (HA) | 6.3 x 10−4 | 3.0 x 10−3 | 4.9 x 10−3 | 7.4 x 10−3 | 1.0 x 10−2 | 3 |
| H81A (HA) | 1.5 x 10−7 | 1.9 x 10−6 | 3.3 x10−6 | 6.0 x 10−6 | 1.1 x 10−5 | 2 |
| W61A (HA) | 1.1 x 10−6 | 8.3 x 10−6 | 1.3 x 10−5 | 2.0 x 10−5 | 3.5 x 10−5 | 2 |
| W61A (CLIP) | 1.3 x 10−5 | 8.5 x 10−5 | 1.3 x 10−4 | 2.1 x 10−4 | 3.3 x 10−4 | 1 |
Rates are expressed in units of s−1.
