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. 2010 Jul 27;16(3):281–290. doi: 10.5056/jnm.2010.16.3.281

Figure 1.

Figure 1

Effect of peripheral administration of the cannabinoid type 1 receptor (CB1R) agonist/antagonist on the electromyograpghy (EMG) to colorectal distension (CRD). (A) Effect of peripheral administration of the CB1R agonist/antagonist on the EMG to CRD of partial restraint stressed rats (day 5). EMG amplitude expressed as mean change from baseline after treatment with vehicle, ACEA or SR141716A in rats exposed to repeated partial restraint stress. Intraperitoneal injection of ACEA abolished the chronic stress-enhanced EMG to CRD compared with vehicle at the pressures of distention of 40, 60 and 80 mmHg. Meanwhile, intraperitoneal injection of SR141716A had an exacerbated effect to the chronic stress-enhanced EMG to CRD compared with vehicle at the pressures of distention of 40, 60 and 80 mmHg. (B) Effect of peripheral administration of the CB1R agonist/antagonist on the EMG to CRD of sham PR rats (day 5). EMG amplitude expressed as mean change from baseline after treatment with vehicle, ACEA or SR141716A in rats exposed to chronic sham PR. ACEA or SR141716A did not affect the EMG response after chronic sham PR compared with vehicle. Data are expressed as mean ± SE, n = 8 in each group, *p < 0.05 significantly different compared with vehicle, 1-way ANOVA.